SnapShot: Molecular Chaperones, Part II

SnapShot: Molecular Chaperones, Part II

SnapShot: Molecular Chaperones, Part I

SnapShot: SMC Protein Complexes Part II

This second of two SnapShots on SMC proteins depicts their roles at different stages of the eukaryotic cell cycle. The composition and architecture of SMC protein complexes and their regulators appear in SMC Protein Complexes Part I (available at http://www.cell.com/cell/pdf/S0092-8674%2815%2901690-6.pdf). To view this SnapShot, open or download the PDF.

Molecular Chaperones

In most cases proteins fold spontaneously under physiological conditions and do not require any external assistance. This has become evident since the experiments on ribonuclease A conducted by Anfinsen in ‘50s and ‘60s. The list of such “successful” folders has grown since and now includes many two-state proteins catalogued in Folding & Design 3, R81. These proteins fold rapidly and reliably t...

PART I: Snapshot appendicitis

Snapshot’ research is a new multicenter study method which is particularly suited to investigate a common condition or treatment. These (mostly observational) studies are primarily initiated and conducted by trainees. Because of a good research network of these trainees, a large amount of data can be collected in a short period while the workload for each participating hospital remains limited....